Boston Millennia Partners Press Releases 2008

Boston, MA - January 25, 2008
PAREXEL Hits New Peak Market Cap of $1.6 Billion
A. Dana Callow, Jr. is pleased to highlight that, as a result of the company’s better-than-expected fiscal 2nd-quarter results, shares of Parexel International Corporation (PRXL) traded at an all time high on January 24, 2008, reaching a peak price of $58.38 and a market value of over $1.6 billion.

Portfolio Company Press Releases 2008

Lexington, MA - December 22, 2008
EPIX Pharmaceuticals Announces FDA Approval of Vasovist(R) (gadofosveset trisodium)
EPIX announced that the FDA has approved for marketing its novel blood pool magnetic resonance angiography (MRA) agent, Vasovist(R) (gadofosveset trisodium), to evaluate aortoiliac occlusive disease (AIOD) in adults with known or suspected peripheral vascular disease.

Cambridge, MA - December 9, 2008
CombinatoRx Presents New Data on B-Cell Malignancy Programs
Synergistic with Standard of Care and Emerging Therapies -
CombinatoRx announced the presentation of new preclinical data on its B-cell malignancy programs at the 50th Annual Meeting of the American Society of Hematology in San Francisco, California.

Boston, MA - December 9, 2008
PHT Corporation Partners with CMARC to Offer the Disabled Independence Through Employment
PHT Corporation is working with Boston-area company CMARC to help people with disabilities. CMARC is a leader in developing programs and services for people with disabilities and over the past 40 years has helped more than 3,000 people lead more independent lives.

Boston, MA - November 13, 2008
MedAptus Announces Organizational and Management Changes
MedAptus announced changes to its senior management team resulting from the promotion of two seasoned employees. These changes largely stem from recent corporate expansion and increased focus on marketing efforts of the company’s newer Facility Intelligent Charge Capture offerings.

Boston, MA - October 29, 2008
PHT Shares ePRO's Message of Improved Data Quality, Safer Trials to Scientific Audiences Worldwide
PHT Corporation, the leading provider of eDiary ePRO solutions used in more than 360 clinical trials worldwide, continues to move the industry forward with it’s dominance in thought conferences.

Cambridge, MA - October 6, 2008
CombinatoRx Announces Top-Line Results from Phase 2b Study of Synavive(TM) (CRx-102) for Knee Osteoarthritis
CombinatoRx announced preliminary top-line results from COMET-1 (CRx-102 Osteoarthritis Multi-center Evaluation Trial), the Company's Phase 2b clinical trial designed to evaluate the safety and efficacy of Synavive (CRx-102) in subjects with symptomatic knee osteoarthritis (OA).

Boston, MA - September 23, 2008
MedAptus Extends Cardiology Presence for Charge Capture, Electronic Prescribing
MedAptus announced that its Practice Plus Edition was recently selected by Virginia Cardiovascular Specialists (VCS), the premier cardiovascular practice in the central Virginia region.

Palo Alto, CA - September 21, 2008
Coapt Systems Launches FDA Cleared Novielle Voice™ For Restoration Of Voice Loss
Coapt Systems Inc. announced the launch of its Novielle Voice family of injectable fillers at the 112th annual meeting of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) in Chicago, IL, September 21-24, 2008.

Lexington, MA - September 16, 2008
EPIX Pharmaceuticals Achieves Milestone from Collaboration with Cystic Fibrosis Foundation Therapeutics
EPIX announced that it has achieved another milestone in its collaboration with Cystic Fibrosis Foundation Therapeutics, Inc. (CFFT), the nonprofit affiliate of the Cystic Fibrosis Foundation. As a result, EPIX will receive $500,000 from CFFT

Waltham, MA - September 2, 2008
Histogenics Secures $9 Million in Second Round of Financing
Histogenics Corporation has closed a $9 million Series B round of equity financing led by Boston Millennia Partners.

Boston, MA - August 26, 2008
PHT Awarded CDISC Certification for Archive of Clinical Research Data
PHT Corporation announced that the Clinical Data Interchange Standards Consortium (CDISC) has certified PHT StudyWorks™ as compliant to their standard.

San Diego, CA - August 12, 2008
Journal of the American Dental Association Publishes Key Clinical Data for the Use of OraVerse™ a Local Anesthetic Reversal Agent
Novalar Pharmaceuticals, Inc. announced the publication of three clinical trials on the use of OraVerse (phentolamine mesylate) injection as a local dental anesthetic reversal agent in the August 2008 issue of the Journal of the American Dental Association (JADA).

Boston, MA - August 5, 2008
PAREXEL Reports Fourth Quarter and Fiscal Year 2008 Financial Results
PAREXEL reports record quarterly and Fiscal Year service revenue grows approximately 33% and 30%, respectively, operating margin of 9.9% for the quarter and record backlog of over $2 billion; net book-to-burn ratio of 1.56 for the quarter

Lexington, MA - August 5, 2008
Financing Facility May Provide EPIX Up To $50 Million of Capital
EPIX Pharmaceuticals, Inc. announced that it has entered into a Committed Equity Financing Facility (CEFF) with Kingsbridge Capital Limited, a private investment group.

MarketWatch - July 29, 2008
New Hope for Alzheimer's Patients
For Alzheimer's victims, help could be on it way. A new generation of drugs could not only alleviate symptons, but could stop progression of the devastating disease.

Cambridge, MA - July 23, 2008
CombinatoRx Highlights Progress in Key Programs at 2008 R&D Day
CombinatoRx, Incorporated (provided a detailed review of selected therapeutic programs and a general company update at its annual Research and Development (R&D) day at its corporate headquarters in Cambridge, MA.

Boston, MA - July 23, 2008
PHT's Valdo Arnera, MD, Named to PharmaVOICE 100 Most Inspiring People in Life Sciences
PHT Corporation announced that its European General Manager, Valdo Arnera, MD, is one of PharmaVOICE magazine’s 100 most inspiring people in life sciences.

Boston, MA, July 22, 2008
ClinPhone Shareholders Approve Acquisition by PAREXEL
PAREXEL International Corporation provided an update with regard to the previously announced proposal whereby an indirect wholly owned subsidiary of PAREXEL will acquire the entire issued and to be issued ordinary share capital of ClinPhone plc.

Cumberland, RI - July 16, 2008
Collegium Pharmaceutical Announces U.S. Patent Issued Covering its DETERx™ Abuse Deterrent Sustained Release Technology
Collegium Pharmaceutical, Inc. announced that a new patent has been issued by the U.S. Patent and Trademark Office (USPTO) relating to its tamper resistant, abuse-deterrent formulation platform.

Cumberland, RI - July 15, 2008
Collegium Pharmaceutical Announces Completion of Series D Financing
Collegium Pharmaceutical, Inc., announced today that it has closed a $20 million Series D equity financing.

Franklin, MA - June 23, 2008
Arthrosurface Receives CE Mark Approval for Uni Knee Resurfacing System
Arthrosurface, Inc. announced that it has received the CE Mark approval for its UniCAP™ Unicondylar resurfacing system. With this approval, the company is poised to move into the fast growing European market of partial knee replacements.

Boston, MA - June 23, 2008
PHT Expands LogPad eDiary Portfolio with Proven Windows Mobile® Devices by Hewlett-Packard
PHT Corporation announced the groundbreaking LogPad™ ePRO system is now available on the Windows Mobile platform as well as the Palm® operating system.

Boston, MA - June 13, 2008
PAREXEL Reaches Agreement to Acquire ClinPhone
PAREXEL International Corporation announced that the Boards of PAREXEL International and ClinPhone plc, have reached agreement on the terms of a recommended proposal whereby a wholly owned subsidiary of PAREXEL will acquire the entire issued and to be issued ordinary share capital of ClinPhone.

Lexington, MA - June 11, 2008
EPIX Pharmaceuticals Initiates Second Trial in Phase 2b Program for Alzheimer's Disease
EPIX announced that it has begun the second trial in its Phase 2b program in Alzheimer's disease. This second Phase 2b trial will evaluate PRX-03140, a novel 5-HT4 agonist, as monotherapy for the treatment of Alzheimer's disease.

Lexington, MA - June 5, 2008
EPIX Pharmaceuticals Achieves Milestone For Third Discovery Program in Collaboration with GlaxoSmithKline
EPIX Pharmaceuticals, Inc. announced that it has achieved a key milestone related to the third of three discovery programs under its collaboration with GlaxoSmithKline (NASDAQ: GSK).

Chicago Tribute Web Edition - June 3, 2008
Staying active with toe implant
Those who suffer from hallux rigidus, or degenerative arthritis of the big toe, have new reason to lace up their gym shoes. A new cartilage resurfacing implant may allow these patients to maintain their active lifestyle.

Waltham, MA - May 30, 2008
Histogenics Appoints Ken Andrews President and CEO
Histogenics Corporation has named F. Ken Andrews as President and Chief Executive Officer

Johnston, Iowa - May 19, 2008
Iowa Corn Checkoff Collaborates With Biotech Firm Athenix to Develop Nitrogen-Efficient Hybrids
The Iowa Corn Promotion Board (ICPB) is collaborating with Athenix Corp. to develop hybrids that are more efficient in using nitrogen fertilizer. These new hybrids could result in improved economics on the farm, reduced impact on the environment and reduced energy requirements to grow the corn crop.

Palo Alto, CA - April 30, 2008
Coapt Systems New CEO, Laureen DeBuono, To Fuel Company's Growth And Product Innovation
Coapt Systems, Inc. announced the appointment of Laureen DeBuono as its President and CEO. DeBuono has more than 25 years of management experience in the medical device and technology markets.

Palo Alto, CA - September 18, 2008
Coapt Systems Announces Two Key Executive Appointments In Worldwide Marketing, Sales, Research And Development
Coapt Systems Inc. announced today the appointments of David Barella as Senior Vice President, Global Marketing and Sales, and Bader Bellahsene, PhD, as Vice President, Research, Development and Manufacturing.

Boston, MA - March 26, 2008
MedAptus’ Facility Charge Capture and Infusion Services Module Purchased by M. D. Anderson Cancer Center
MedAptusannounced that its customer, The University of Texas M. D. Anderson Cancer Center, is implementing the company’s Facility Charge Capture and Infusion Services Module solutions.

Atlanta, GA - March 20, 2008
DCA Life Sciences Facilities Fund Program Completes $2M Loan to CardioMEMS
Georgia Department of Community Affairs (DCA) Commissioner Mike Beatty announced the closing of a $2,000,000 loan to CardioMEMS, Inc. through its Life Sciences Facilities Fund (LSFF) Program.

Cambridge, MA - March 12, 2008
CombinatoRx Drug Candidate CRx-191 Demonstrates Positive Phase 2 Results in Psoriasis
CombinatoRx, Incorporated announced top line results of its randomized, blinded, placebo-controlled Phase 2 proof-of-concept clinical trial of CRx-191 in plaque psoriasis.

Boston, MA - March 3, 2008
PHT to Unveil Revolutionary SitePadTM Tablet for Site-Based Questionnaire Data Capture at DIA EuroMeeting
PHT Corporation, the leading provider of electronic patient reported outcome (ePRO) solutions used in more than 345 clinical trials worldwide, will reveal the future of site-based questionnaire data capture at the 20th Annual DIA EuroMeeting in Barcelona, 3-5 March 2008.

Cambridge, MA - February 26, 2008
CombinatoRx Granted Broad Patent Covering TCA-Glucocorticoid Combinations
CombinatoRx, Incorporated announced that it has been granted a United States entitled "Combinations for the treatment of inflammatory disorders" with broad composition of matter and method of use claims covering combinations of tricyclic antidepressants (TCA) and glucocorticosteroids.

Boston, MA - February 13, 2008
Dana-Farber Cancer Institute Completes Deployment of MedAptus’ Infusion Services Module
MedAptus announced that its customer, the prestigious Dana-Farber Cancer Institute, has completed enterprise-wide deployment of the company’s Infusion Services Module.

Bridgewater, NJ - February 12, 2008
Sapphire Therapeutics Promotes Suzan Allen to Vice President Clinical Operations
Sapphire Therapeutics announced the promotion of Suzan Allen to Vice President Clinical Operations.

Research Triangle Park, N.C. - January 31, 2008
Athenix and Syngenta in R&D Partnership for Advanced Biotechnology Corn Insect and Soybean Nematode Control Traits
Athenix Corp. announced that it has entered into an agreement with Syngenta for the discovery of novel corn insect and soybean cyst nematode resistance genes. Syngenta is a world-leading agribusiness committed to sustainable agriculture through innovative research and technology.

Cambridge, MA - January 24, 2008
CombinatoRx Provides Goals and Guidance for 2008
"2008 promises to be an exciting and pivotal year for CombinatoRx with clinical data expected from CRx-102, 191, 197 and 401," said Alexis Borisy, President and CEO of CombinatoRx. "We also continue to maintain a steady flow of novel programs into clinical development, remain on track ..."

Lexington, MA - January 23, 2008
EPIX Pharmaceuticals Achieves $1.25 Million Milestone in Collaboration with Cystic Fibrosis Foundation Therapeutics
EPIX Pharmaceuticals, Inc. announced that it has received a $1.25 million milestone payment from Cystic Fibrosis Foundation Therapeutics, Inc. (CFFT), the nonprofit affiliate of the Cystic Fibrosis Foundation.

Boston, MA - January 17, 2008
PHT Convenes Pharmaceutical Industry Innovators at Fifth Annual U.S. User Group Meeting
PHT Corporation recently held its fifth annual User Group Meeting in Orlando.

Petaluma, CA - January 16, 2008
Volcano Communications Deploys Ethernet-based Calix E-Series Platform
Calix announced that Volcano Communications, an innovative California-based service provider, has successfully deployed the Calix E5-100 Ethernet Service Platform (ESP) to deliver very high bandwidth services to its customers.

Dambury, Conn. - January 15, 2008
Odyssey Logistics & Technology Corporation and Hercules Incorporated Finalize New Contract
Odyssey Logistics & Technology Corporation today announced that Hercules Incorporated (NYSE: HPC), a global specialty chemicals company, has signed a new four-year agreement with Odyssey to continue to manage its North American transportation operations.

Stockholm, Sweden - January 14, 2008
Aptilo Networks Acquires Airpath Wireless
Aptilo Networks, the global leader in integrated solutions for Service Management and Access Control for wireless networks including WiMAX, metro Wi-Fi and Wi-Fi hotspots, announced today that the company has acquired Airpath Wireless, Inc.

Costa Mesa, CA - January 14, 2008
MegaPath Launches ADSL+ High-Speed Internet Connectivity Service
MegaPath Inc. announced its ADSL2+ Internet Connectivity Service.

Boston, MA - January 10, 2008
PHT and Sucampo Pharmaceuticals Present ePRO/EDC Data Integration Case Study at CBI Premier Conference on PRO
PHT Corporation and Sucampo Pharmaceuticals (Nasdaq:SCMP) introduced an innovative eClinical data integration case study at the Center for Business Intelligence (CBI)’s Premier Conference on Patient Reported Outcomes recently in Washington, D.C.

Costa Mesa, CA - January 8, 2008
MegaPath Receives Internet Telephony® Magazine's 10th Annual Product of the Year Award
MegaPath Inc. announced that Technology Marketing Corporation’s (TMC®) INTERNET TELEPHONY magazine has named MegaPath’s Duet Voice and Data solution as a 2007 Product of the Year Award winner. INTERNET TELEPHONY has been the VoIP Authority Since 1998™.

Petaluma, CA - January 8, 2008
Calix Ships GPON ONTs with Standards-based RF Return
Calix announced the availability of the first gigabit passive optical network (GPON) optical network terminal (ONT) that utilizes standards-based radio frequency over glass (RFOG) technology for two-way communication with RF-enabled consumer devices.

Sunnyvale, CA - January 8, 2008
Tropos Networks Announces Veteran Sales Executive as New President and CEO
Tropos® Networks announced the appointment of veteran sales executive Tom Ayers as President and CEO to head the company.

Dedham, MA - January 3, 2008
iParty Corp. Reports Purchase of Two Party City Stores in Rhode Island
iParty Corp reported that it has completed the acquisition of two retail party goods stores in Lincoln, Rhode Island and Warwick, Rhode Island, previously operated as Party City franchise stores.